HPLC测定清胃散拆方中的盐酸巴马汀等成分

Determintion of palmatine hydrochloride,jatrorrhizine hydrochloride and paeoniflorin in different compatibility for Qingwei powder

目的研究清胃散拆方中盐酸巴马汀、盐酸药根碱、芍药苷的转移率及变化规律。方法采用HPLC测定清胃散拆方中盐酸巴马汀、盐酸药根碱及芍药苷的转移率。结果黄连中盐酸巴马汀和盐酸药根碱的溶出与其他生药存在相互影响;配方中各生药对芍药苷的溶出影响较小。结论实验结果可对复方清胃散在临床上合理运用提供参考。

OBJECTIVE To investigate the contents and variations of palmatine hydrochloride, jatrorrhizine hydrochloride and paeonifiorin in different compatibility for Qingwei powder. METHODS The contents of palmatine hydrochloride, jatrorrhizine hydrochloride and paeoniflorin in different compatibility for Qingwei powder which were determined by HPLC. RESULTS The dissolution of palmatine hydrochloride and jatrorrhizine hydrochloride from coptis in the decoction was affected by other traditional medicines in the same decoction ; but the dissolution of paeonifiorin was effected very slightly. CONCLUSION The results can be provided as a reference for Qingwei powder in clinical application.