注射用盐酸雷莫司琼与4种输液配伍的稳定性考察

Compatibility of ramosetron hydrochloride for injection with four kinds of injections

目的考察注射用盐酸雷莫司琼在5%葡萄糖注射液等4种输液中的稳定性。方法在25℃,将注射用盐酸雷莫司琼加入到4种输液中,模拟临床用药浓度,用高效液相色谱法测定配伍后不同时间配伍液的含量,同时检查配伍液的pH值和外观变化。结果注射用盐酸雷莫司琼与4种输液配伍后在25℃放置10 h其外观、pH值和含量基本不变。结论注射用盐酸雷莫司琼与4种输液配伍,在10 h内基本稳定。

Aim To investigate the compatibility of ramosetron hydrochloride for injection with four kinds of injection solutions. Methods Changes of content, pH and appearance of ramosetron hydrochloride for injection within 10 hours under 25℃ after combination with respective injections as simulated clinic therapy concentration were measured and observed. Results Significant changes of appearance, pH and content had not been observed within 10 hours under 25℃, when ramosetron hydrochloride for injection was combined with four kinds of injection solutions respectively. Conclusion It is stable within 10 hours under 25℃ after ramosetron hydrochloride for injection was combined with four kinds of injection solutions.