128例慢性乙型肝炎微循环与肝组织病理关系的相关性研究

Correlation Study between the Microcirculation and the Pathology of Liver Tissue in 128 Cases of Chronic Hepatitis B(CHB)

目的观察128例慢性乙型肝炎微循环与肝脏炎症活动程度(G1-4)分级、病理纤维化程度(S0-4)分期间的相关性。方法肝穿刺组织学检查:根据炎症分级分为G1-2组和G3-4组。根据肝纤维化分期分为2组:S0-1组和S2-4组。用微循环检测仪观测甲襞微循环。结果甲襞微循环加权积分随肝脏炎症和纤维化程度的加重而增加,总积分:G1-2组(2.53±1.76),G3-4组(4.45±1.65),差异有统计学意义(P<0.01);S0-1组(2.78±1.43),S2-4组(4.12±1.32),差异有统计学意义(P<0.01)。结论慢性乙型肝炎外周微循环变化与肝脏病理炎症分级和纤维化程度分期具相关性。

Objective TO observe the relationship of microcirculation with degree of hepatic inflammatory activity and hepatic fibrosis in 128 cases of CHB. Methods According to the degree of hepatic inflammatory activity,patients were divided into mild inflammatory group （G1-2 ） and severe inflammatory group（ G3-4 ） ;According to the stage of hepatic fibrosis, patients were divided into group （ S0-1 ） and group （ S2-4 ）. Nailfold mierocirculation was detected by detector of microcirculation. Results Multiple scores of nailfold microcirculation increased with the aggravation of hepatic inflammation and fibrosis. Total multiple scores： Group （ G1-2 ） was （ 2.53 ± 1.76） ,group （G3-4） was （4.45± 1.65 ） ,P 〈 0.01 ;group （ S0-1 ） was （ 2.78±1.43 ） ,group （ S2- 4） was （4.12 ± 1.32） ,P 〈0.01. Conclusions The change of the microcirculation is correlative with the degree of hepatic inflammatory activity and hepatic fibrosis.