足细胞损伤与蛋白尿足细胞损伤与蛋白尿
摘要
蛋白尿是肾小球疾病的主要表现之一,近年来肾病学者对足细胞损伤与蛋白尿发生的关系进行了深入研究,且不断有新的发现和认识,本文就足细胞的损伤与蛋白尿的关系作一综述。
出处
《国际泌尿系统杂志》
2008年第1期140-144,共5页
International Journal of Urology and Nephrology
参考文献30
-
1Katsuhiko A, Isao S, Kazumi I, et al. Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes. Kidnev Int, 2002,62(3):822 -831.
-
2Saleem MA, Ni L, Witherden I, et al. Co - localization of nephrin, podocin, and the actin cytoskeleton :evidence for a role in podocyte foot process formation. Am J Pathol, 2002,161 (4) :1459 -1466.
-
3Kim YH, Goyal M, Kurnit D, et al. Podoeyte depletion and glomerulosclerosis have a relationship in the PAN - treated rat. Kidney Int, 2001,60 (3):957 - 968.
-
4Wu DT, Bitzer M, Ju W, et al. TGF - beta concentration specifies differential signaling profiles of grouth arrest/differentiation and apoptosis in podocytes. J Am Soc Nephrol, 2005,16 ( 11 ) :3211 - 3221.
-
5Ding G, Reddy K, Kapasi AA. et al. Angiotensin Ⅱ induces apoptosis in rat glomerular epithelial cells. Am J Renal Physiol, 2002,283 (1) :F173 - F180.
-
6Sanwal V, Pandya M, Bhaskaran M, et al. Puromycin aminnnucleoside induces glomerular epithelial cell apoptosis. Epxt Mol Path. 2001,70( 1 ) :54 -64.
-
7Hara M, Yanagihara T, Kihara I. Urinary podoeytes in primary focal segmental glomerulosclerosis. Nephron, 2001 ,89 (3):342 - 347.
-
8Petermann AT, Krofft R, Blonski M. et al. Podocytes that detach in experimental membranous nephropathy are viable. Kidney Int, 2003, 64(4) :1222 - 1231.
-
9Marshall CB, Shanklaud SJ. Cell cycle regulatory proteins in podoeyte health and disease. Nephron Exp Nephrol, 2007,106 (2):e51 -59.
-
10Srivastava T, Garola RE, et al. Cell - cycle regulatory proteins in podocytecell in idiopathic nephrotic syndrome of childhood. Kidney Int, 2003,63 (4) :1374 - 1381.
二级参考文献20
-
1Pavenstadt H,Kriz W,Kretzler M.Cell biology of the glomerular podocyte.Physiol Rev,2003,83(1):253-307.
-
2Shih NY,Li J,Karpitskii V,et al.Congenital nephrotic syndrome in mice lacking CD2-associated protein.Science,1999,286(5438):312-315.
-
3Kim JM,Wu H,Green G,et al.CD2-associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility.Science,2003,300(5623):1298-1300.
-
4Dustin ML,Olszowy MW,Holdorf AD,et al.A novel adaptor protein or chestrates receptor patterning and cytoskeletal polarity in T-cell contacts.Cell,1998,94(5):667-677.
-
5Li C,Ruotsalainen V,Tryggvason K,et al.CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.Am J Physiol Renal Physiol,2000,279(4):785-792.
-
6Lehtonen S,Zhao F,Lehtonen E.CD2-associated protein directly interacts with the actin cytoskeleton.Am J Physiol Renal Physiol,2002,283(4):F734-F743.
-
7Schwarz K,Simons M,Resier J,et al.Podocin,a raft-associated component of the glomerular slit diaphragm,interacts with CD2AP and nephrin.J Clin Invest,2001,108:1621–1629.
-
8Huber TB,Hartleben B,Kim J,et al.Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.Mol Cell Biol,2003,23:4917–4928.
-
9Grunkemeyer JA,Kwoh C,Huber TB,et al.CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency.J Biol Chem,2005,280(33):29677-29681.
-
10Gassler N,Elger M,Kranzlin B,et al.Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker rat.Kidney Int,2001,60:106-116.
共引文献2
-
1常沁涛,张强,武明虎.足细胞相关蛋白与蛋白尿[J].山西医科大学学报,2007,38(3):270-273. 被引量:1
-
2陈雪妍,綦向军,卢以茜,罗冬强,张兆萍,林樫,陈月梅,方彩珊,陈国铭,陈刚毅.黄芪注射液治疗慢性肾脏病的Meta分析及试验序贯分析[J].中医药导报,2020,26(16):176-181. 被引量:4
-
1沈晓刚,沈汉超.糖尿病肾病足细胞损伤的研究进展[J].国外医学(泌尿系统分册),2005,25(5):680-684. 被引量:2
-
2唐英,蒋宇锋,邹赟,张昕贤,何立群.IgA肾病足细胞损伤机制及中医药治疗的研究进展[J].中国中西医结合肾病杂志,2016,17(8):744-746. 被引量:4
-
3姜文玲(综述),彭佑铭(综述),刘虹(综述).足细胞损伤与IgA肾病[J].国际泌尿系统杂志,2009,29(5):704-708. 被引量:2
-
4李振勇,倪兆慧.足细胞损伤的干预研究进展[J].国际泌尿系统杂志,2006,26(4):547-550. 被引量:4
-
5向少伟(综述),王小琴(审校).转化生长因子-β1介导的足细胞损伤[J].国际泌尿系统杂志,2008,28(4):559-563. 被引量:1
-
6张萍,邹玉蓉,李贵森,汪伟.2例膜性肾病患者足细胞内陷性病理改变的观察[J].临床肾脏病杂志,2011,11(10):438-438.
-
7韩润鸿,刘丽秋.自噬对肾小球疾病的影响[J].国际泌尿系统杂志,2015,35(1):139-143. 被引量:1
-
8王相相,袁军.从中西医角度浅析足细胞与神经元的相似之处[J].湖北中医杂志,2017,39(1):62-64.
-
9梁丹丹,曾彩虹.局灶节段性肾小球硬化的发病机制[J].肾脏病与透析肾移植杂志,2009,18(1):70-75. 被引量:4