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多种靶向药物联合治疗骨髓增生异常综合征的临床研究 被引量:5

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摘要 目的观察联合多种靶向药物治疗骨髓增生异常综合征(MDS)的近期疗效。方法应用全反式维甲酸(ATRA)、反应停、丙戊酸、安特尔联合治疗MDS 8周,其中RAEB-T另加用高三尖杉酯碱(Har)化疗。结果低危(RA)2例进步,中危(RAEB)4例,PR 1例,无效3例,高危(RAEB-T)1例PR。总有效率57%。结论ATRA、反应停、丙戊酸、安特尔联合治疗MDS疗效较好,对高危患者联合化疗疗效更好。
出处 《现代中西医结合杂志》 CAS 2008年第8期1186-1187,共2页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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  • 1Nakagawa T, Matozaki S, Murayama T, et al. Establishment of a leukemic cell line from a patient with acquisition of chromosomal abnormalities during disease progression in myelodysplastic syndrome.BrJ Haematol, 1993; 85:469-476
  • 2Siavoshian S, Blottiere HM, Cherbut C, et al. Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells. Biochem Biophys Res Commun,1997; 232:169 - 172
  • 3Nakagawa T, Matozaki S. The SKM-1 leukemic cell line established from a patient with progression to myelomonocytic leukemia in myelodysplastic syndrome (MDS)-contribution to better understanding of MDS. Leuk Lymphoma, 1995; 17: 335- 339
  • 4Dimberg A, Bahram F, Karlberg Ⅰ, et al. Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27 (Kip1). Blood, 2002; 99: 2199 -22
  • 5Harper JW, Elledge SJ, Keyomarsi K, et al. Inhibition of cyclindependent kinases by p21. Mol Biol Cell, 1995; 6: 387-400
  • 6Kawaguchi R, Hosokawa Y, Komine A, et al. The monocytic cell line SKM-1 strongly expresses the myeloperoxidase gene. Leukemia, 1992; 6: 1296-1301
  • 7Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood,2002; 100:2292 - 2302
  • 8Wong H, Anderson WD, Cheng T, et al. Monitoring mRNA expression by polymerase chain reaction: the ""primer-dropping"" method. Anal Biochem, 1994; 233:251-258
  • 9Marks PA, Richon VM, Rifkind RA. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst, 2000; 92:1210 1216
  • 10Drexler HG. Malignant hematopoietic cell lines: in vitro models for the study of myelodysplastic syndromes. Leuk Res, 2000; 24:109-115

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