敌百虫对鲤鱼组织乙酰胆碱酯酶和腺三磷酶活力的影响

Effects of Dipterex on the AChE and ATPase Activities in Common Carp(Cyprinus carpio) Tissues

在系列浓度的敌百虫农药暴露中，鲤鱼脑乙酰胆碱酯酶（Ａｃｅｔｙｌ－ｃｈｏｌｉｎｅｓｔｅｒａｓｅ，ＡＣｈＥ）和鳃、肾腺三磷酶（Ａｄｅｎｏｓｉｎｅｔｒｉｐｈｏｓｐｈａｔａｓｅ，ＡＴＰａｓｅ）的敏感性依次为脑ＡＣｈＥ＞肾ＡＴＰａｓｅ＞鳃ＡＴＰａｓｅ。引起死亡的脑ＡＣｈＥ抑制率在急性暴露中可大于９５％，而鳃、肾ＡＴＰａｓｅ抑制率达５０％～６０％时，鱼通常难以存活。实验结果表明，ＡＣｈＥ抑制并非是有机磷农药中毒中引起死亡的唯一原因，非胆碱能毒性作用也具有重要的作用。

When fishes exposed to a series of concentrations of Dipterex, the activities of enzymes in the tissues were: brain AChE>kidney ATPase>gill ATPase. The inhibition associated with death in acute toxicity experiment in brain AChE activity could reach as high as 95%, while the inhibition associated with death in gill ATPase and kidney ATPase was 50%～60%. The results showed that AChE inhibition was not the only factor involved in the death caused by organophosphate pesticide poisoning, the noncholinergic toxicity also contributed to the death.