头孢泊肟酯的合成

Synthesis of Cefpodoxime Proxetil

三光气和乙醛反应得到的1-氯乙基氯甲酸酯,与异丙醇酯化后再经NaI碘代得1-碘乙基异丙基碳酸酯(2),收率为43.7%。2和头孢泊肟进行酯化得到头孢泊肟酯,收率70%。

1-Iodoethyl isopropyl carbonate （2）, prepared from 1-chloroethyl chloroformate in 43.7 % yield was used to prepare cefpodoxime proxetil by esterification with cefpodoxime in 70% yield.