针刺对抑郁模型大鼠行为学的影响

Effects of Acupuncture on Behavior Changes of Depressed Model Rats

目的实验观察针刺对抑郁模型大鼠行为学的影响。方法以220 V,0.8 mA的方波刺激Wistar大鼠15 s,间隔45s/次,共60次,总刺激时间15 min,进行不可逃避的前休克动物(pre-shocked animals)制作,形成学习无助大鼠模型,采用Open-Field法进行动物行为学敞箱实验及条件回避实验,观察针刺对模型大鼠行为学的影响。结果针刺对学习无助模型大鼠水平及垂直运动均有明显改善,且显著提高大鼠的逃避成功次数、缩短逃避潜伏期(P<0.01)。结论针刺可明显改善抑郁症状,促进抑郁症恢复。

Objective To observe the effect of acupuncture on behavior changes in the Wistar rats of depression. Methods 40 male Wistar rats were randomly divided into 4 groups, namely acupuncture group, drug group, model group and normal control group. The rats were stimulated 15 minutes by quadratal wave of 220v, 0.8mA to make Wistar rat model of studying helplessness. The animal behavioral spacious box testing and conditioned avoidance testing were performed with the method of Open - Field. Resuits The crossing and rearing score of model rats were obviously improved and the time of successful avoidance was obviously enhanced by acupuncture, as well as shorten avoidance latent period（ P 〈 0.01 ）. Conclusion Acupuncture can obviously improve the symptoms of depression.