食管癌后程加速超分割放疗配合化疗及丹参的疗效观察

Clinical Observation on the Treatment of Caicinoma of Esophagus with Later Coures Accelerated Hyperfractionation Combined with Chemotherapy and Radix Salivae Miltiorrhizae

目的探讨食管癌后程加速超分割放疗配合化疗及丹参的疗效。方法将60例确诊的食管癌患者随机分为两组,后程加速超分割放疗配合化疗及丹参组(简称后超组)和常规分割放疗组(简称常规组),观察两组治疗效果及毒副作用。结果后超组1,2,3年局部控制率及生存率均好于常规组(P<0.05)。白细胞下降、胃肠道反应及放射性肺炎等两组比较无显著差异(P>0.05)。结论食管癌后程加速超分割放疗配合化疗及丹参疗效确切,且毒副反应可接受,值得临床推广应用。

Objective To explore the clinical effects of later course accelerated hyperfractionation combined with chemotherapy and Radix Salivae Miltiorrhizae in the treatment of carcinoma of esophagus. Methods 60 patients with carcinoma of esophagus were divided into experimental group （treated with later course accelerated hyperfractionation combined with chemotherapy and Radix Salivae Miltiorrhizae） and control group （treated with routine radiotherapy） randomly. The clinical effects and toxic actions were observed. Results The local control rate and the survival rate of the experimental group were better than those of the control group（ P 〈 0.05 ）. There were no significant difference between the two groups concerning the reaction of gastrointestinal tract and the decrease of white ceils （P 〉0.05）. Condttsion Later course accelerated hyperfractionation is quite effective in treating carcinoma of esophagus, its toxic actions are acceptable, and is worth expaoding in clinical practices.