产MonacolinK红曲霉菌的筛选及发酵条件的研究

Screening Monascus Producing Monacolin K and Studying on Its Fermentation Condition

对１２种４２株红曲霉菌进行ＭｏｎａｃｏｌｎＫ产生情况筛选。其中１６株发酵培养物中检测到该生理活性物质的存在，以Ｍｒｕｂｅｒ６１２菌株产量最高，可达４９５μｇ／ｍＬ。对此菌株的发酵条件进行研究，确定出最适碳源、氮源及Ｃ／Ｎ比，给出生产ＭｏｎａｃｏｌｉｎＫ的工艺条件。实验结果表明，培养基组成、温度对产生ＭｏｎａｃｏｌｉｎＫ有制约作用。

42 strains were studied for producing Monacolin K among 12 species Monacolin K was detected in 16 strain culture, and the content of Monacolin K in M ruber 612 were the highest (495μg/mL) among 42 strains 