不同组织材料再造尿道的远期对比观察

The long-term contrastive result of neo-urethra reconstructed with different kinds of tissue

目的对比应用不同组织材料再造尿道内壁的远期外观和组织结构变化及与正常尿道的区别，遴选用于再造尿道的组织材料。方法术中直视或应用尿道造影、尿道镜观察再造尿道内壁外观。应用光镜、电镜观察再造尿道切片组织结构。结果应用皮肤或黏膜再造尿道远期外观均接近正常尿道，远期组织结构也未见改变；应用口腔黏膜再造的尿道，远期组织结构还具备形成正常尿道微环境的一些重要结构基础；应用膀胱黏膜者，远期组织结构接近正常尿道。结论膀胱黏膜和口腔黏膜可能是较皮肤更适用于再造尿道的组织材料。

Objective To observe the long-term apparent and structural change of the neo-urethra inner wall reconstructed with different kinds of tissue. To compare the difference between normal and reconstructed urethra for urethra reconstruction with more appropriate materials. Methods The rico-urethra inner wall was observed during operation, through urugraphy and urethroscope. The tissue section of neo-urethra inner wall was observed through light microscope and electron microscope. Results With unchanged structure, the appearance of rico-urethra reconstructed with skin or mucosa could be close to normal urethra after a long time. Neo-urethra made of buccal mucosa possesses some of the most important basic structures for normal urethral microenvironment to form. The structure of neo-urethra made of bladder could be close to normal urethra after a long time. Conclusions Buccal and bladder mucosa may be a better material than skin for urethra reconstruction.