老年糖尿病病人和健康人血清铬及尿铬的分析

Serum and urine chromium concentratios of the diabetic and nornmal healthy elderly

对５７例老年糖尿病病人和５５例健康老年人进行了血清铬和尿铬测定。结果显示老年糖尿病病人的空腹血清铬０．２２～０．３６μｇ／Ｌ，尿铬４．５４～５．９０μｇ／Ｌ，明显低于健康老人０．６６～０．８４μｇ／Ｌ和７．８０～９．６８μｇ／Ｌ（Ｐ＜０．０１）。提示糖尿病病人可能缺铬。同时，发现女性糖尿病病人尿铬明显高于男性（Ｐ＜０．０１）；同年龄组的血清铬无差异，但是＞７０岁者尿铬均高于６０～７０岁者；而且高血糖值病人血清铬明显低于低血糖值者，但尿铬值高于高血糖者。结果表明，随着增龄，铬在体内的丢失较多，排泄增加，并与病情相关，故应根据糖尿病老年人的营养状况增加体内铬的来源。

Serum and urine chromium concentrations of 57 diabetics and 55 normal subjects were determined by AAS. The results indicate that the chromium concentration ranges fo serum and urine for diabetics are 0 22～0 36μg/L and 4 54～5 90μg/L, respectively, being significantly lower than 0 66～0 84μg/L and 7 80～9 68μg/L in the normal(P<0 001), which implies that the elderly diabetics is likely lack of trivalent chromium. THe urine chromium level of the female diabetics was substantially higher than that of male diabetics at the same age group(P<0 01), while the serum chromium level was almost the same.However, the urine chromium concentration increases with the aging, no matter the diabetics or the control. The serum chromium concentrations of the patients with the high blood glucose were significantly lower than those of the low blood glucose, while the urine chromium exhibits a contrary tendency. Our data indicate that the chromium excreted from human body increases with the aging and is related to the diabetes. Thus, it is recommended to sapply certain amount of chromium according to the nutritional level of elderly diabetics.