40例骨肉瘤的临床疗效分析

Effectiveness of osteosarcoma(report of 40 cases)

[目的]探讨如何提高骨肉瘤患者的5年生存率。[方法]通过术后5年以上跟踪随访,分析40例骨肉瘤患者的病理类型,临床分期,手术方式,放化疗情况。[结果]全组5年生存率为20%（8/40）,手术加新辅助化疗组5年生存率60%（6/10）,手术加一般化疗组5年生存率为18%（2/11）。两组差异有显著性意义（P〈0.05）。[结论]新辅助化疗的临床应用已使得保肢手术成为骨肿瘤治疗的主要方向。与此同时,骨肉瘤的5年生存率已由原来的10%-20%提高到60%-80%。参照Enek ing分期,采用规范的广泛切除术,也是提高保肢术患者5年生存率的基本条件之一。

[ Objective] To investigate the clinical treatment of patients with osteosarcoma. [ Methods] Clinicaldata of 40 patients with osteosarcoma treated were retrospectively analyzed including image examination, pathologic examination and surgical procedure. [ Results ] The 5 years survival rate of 40 cases of osteosarcoma were 20% （8/40）. The 5 years survival rate of complete resection were 60% （6/10）. The 5 years survival rate of partial resection were 18% （2/11）. [ Conclusions ] To treat osteosarcoma through surgery combined with neoadjuvant Chemotherapy is effective and minimally invasive treatment for patients. The 5 years survival rate of osteosarcoma improves from 10% - 20% to 60% - 80% now. Complete resection is the key for the treatment of osteosarcoma.