摘要
采用分析基因限制性内切酶片段长度多态性技术对96例冠心病患者和95例正常人载脂蛋白AI基因多态性进行检测,并对这一基因变化与高密度脂蛋白的关系进行研究。冠心病组中P_1P_2基因型血浆HDL和apoAI水平明显低于P_1P_1型,P_2等位基因与低α脂蛋白血症有较密切关系。携带P_2等位基因同时伴有血浆HDL和apoAI水平低下者,冠心病的发病率增高,并有早发心肌梗死的危险。
The polymorphism in apolipoprotein AI gene detected with restriction fragment length polymorphism (RFLP ) were used to study the relationship between the genetic variation and high density lipoprotein(HDL). Ninety-six patients with coronary heart disease(CHD)and 95 healthy controls were investigated. CHD patients with the genotype P1P2 had significantly lower plasma levels of HDL-C and apo AI as compared to those with the genotype P1P1 ,P2 allele was significantly associated with hypoal-phalipoproteinemia. Individuals with both P2 allele and lower plasma levels of HDL had increased incidence of coronary heart disease and risk of premature myocardial infarction.
出处
《天津医药》
CAS
1997年第7期391-395,共5页
Tianjin Medical Journal
基金
天津市卫生局资助课题
关键词
载脂蛋白
AI基因
多态性
低α脂蛋白血症
apolipoprotein AI gene restriction fragment length polymorphism hypoal-phalipoproteinemia allele