糖尿病患者尿白蛋白排泄率与血清脂质、纤维蛋白原相关关系的研究

The Relationship between Urinary Albumin Excretion Rate and Serum Lipids and Fibrinogen in Diabetic Patients

探讨糖尿病患者血清脂质、纤维蛋白原(FBG)在糖尿病肾病发展过程中的变化规律。通过检测60例糖尿病患者尿白蛋白排泄率(AER)、血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、载脂蛋白A(apoA)、载脂蛋白B(apoB)及FBG等指标,发现糖尿病患者随尿AER增加,血中TG、TC、LDL-C、FBG逐渐升高,且均与尿AER呈正相关;HDL-C逐渐降低,与尿AER呈负相关。提示:糖尿病肾病可能影响脂质代谢及纤维蛋白原水平,并成为糖尿病肾病患者高心、脑血管并发症的重要危险因素之一。

The regular changes of serum lipids and plasma fibrinogen(FBG)concentration of the diabetic patients in the course of diabetic nephropathy (DN) were studied. The urinary albumin excretion rate (AER),serum triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol(HDL-C),apolipoprotein A(apoA) and apolipoprotein B(apoB) and fibrinogen were measured. The results showed that the concentrations of TG,TC,LDL-C and FBG were increased gradually along with the increasing of urinary AER and were positively correlated with urinary AER in DM. but the concentration of HDL-C decreased gradually and was negatively correlated with urinary AER. It suggested that the disorders of serum lipids and fibrinogen may be influenced by DN. Thus it would be one of risk factors of excess mortality caused by atherosclerosis in DN patients.