摘要
本实验通过离体蟾蜍、大鼠心脏灌流方法观察不同浓度酒精对心脏收缩活动的影响，并探讨其作用机制。结果表明：①酒精减慢离体蟾蜍心脏活动节律，但对最大收缩张力、搏出量和心输出量无明显影响。②酒精对离体大鼠心脏收缩活动有明显影响，可浓度依赖性地降低最大收缩张力、减慢心率和减少冠脉流量。提示，酒精抑制心脏收缩功能，可能是通过其收缩冠脉血管。
The effects of ethanol on the contraction of isolated hearts from toad and rat, and the underlying mechanism were studied. The results showed that:①for the toad heart ethanol lowered the heart rate,but showed no effects on the maximum isometric tension,the stroke volume and the cardiac output; ②ethanol affected the contractile activity of rat heart significantly,as manifested by decreases in maximum isometric tension,heart rate and coronary blood flow in a dose-dependent manner.The results suggest that ethanol may depress the contractile function of isolated heart significantly through the decrease in coronary blood flow induced by contraction of coronary smooth muscle.
出处
《河北医科大学学报》
CAS
1997年第4期203-205,共3页
Journal of Hebei Medical University
关键词
酒精
心肌收缩
蟾蜍
大鼠
myocardial contraction
heart rate
coronary circulation
ethanol
toad
rat
