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抗内皮细胞抗体在系统性红斑狼疮活动判定中的意义 被引量：3

Significance on IgG-antiendothelial Cell Antibody in Determining the Activity of Systemic Lupus Erythematosus
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摘要 目的探讨IgG型抗内皮细胞抗体(IgG-AECA)在系统性红斑狼疮(SLE)活动判定中的意义。方法用间接免疫荧光法检测39例SLE活动期患者、25例SLE缓解期患者及25例健康对照者的血清IgG-AECA及其滴度。结果3组受试者血清IgG-AECA的阳性率间差别有统计学意义(P<0.001);且SLE活动组与对照组IgG-AECA的阳性率间差别有统计学意义(P<0.017)。SLE活动组和缓解组患者IgG-AECA的滴度间差别有统计学意义(P<0.05)。结论SLE活动期患者血清IgG-AECA阳性率及其滴度均高于缓解期,故检测SLE患者血清IgG-AE-CA及滴度可作为SLE活动性指标之一。 Objective To investigate the significance of IgG - antiendothelial cell antibody （ IgG - AECA） in determining the activity of systemic lupus erythematosus （ SLE ）. Methods The serum IgG - AECA and its titer were determined by indirect immunofluorescence （IIF） technique in 39 active SLE patients, 25 remissive SLE patients and 25 healthy controls. Results There was a significant difference in positive rate of IgG - AECA among the patients in the three groups （ P 〈 0. 001 ） , and there were also significant differences between the patients of each two groups （ P 〈 0. 017 ）. The titer level of IgG - AECA in patients of active group is higher than that in patients of remissive group （ P 〈 0. 05 ）. Conclusion The levels of serum IgG - AECA and its titer in patients with active SLE are higher than those in patients with remissive SLE ; so the levels of serum IgG - AECA and its titer could De served as one of indexes to evaluate the activity of SLE .
作者 张双欣 邵福灵 苏丽娜 张芹
机构地区 河北省石家庄市第一医院内科 河北医科大学第二医院免疫风湿科
出处 《中国全科医学》 CAS CSCD 2008年第4期289-290,共2页 Chinese General Practice
关键词 红斑狼疮 系统性 抗体 内皮细胞 血管炎 Lupus erythematosus, systemic Antibodies, endothelial cells Vaseulitis
分类号 R593.241 [医药卫生—内科学]
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参考文献10

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二级参考文献13

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共引文献6

同被引文献21

  • 1Bordron A,Reve1en R,D'Arbanneau F,et a1.Functional heterogeneity of anti-endothelial cell antibodies[J].Clin Exp Immunol,2001,124(3):492.
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  • 3Sail RA,Taysi S,Erdem F,et al.Correlation of serum levels of soluble intercellular adhesion molecule-1 with disease activity in systemic lupus erythematosus[J].Rheumatol Int,2002,21(4):149.
  • 4Carvalho D,Savage CO,Isehberg D,et a1.IgG anti-endothelial cell autobidies from patients with systemic lupus erythematosus of systemic vasculitis stimulate the relase of two endothelial cell-drived mediator,which enhance adhesion molecule expression and leukocyte adhesionin in an autocrine manner[J].Rheumatism,1999,42(4):631.
  • 5Youinou P,Meroni PL,Munther A,et a1.A need for stan gdardization ofthe anti-endothelial cell antibody test[J].Immunology Today,1995,16(8):363.
  • 6Horvathova M,Jahnova E,Nyulassy S.Detection of antiendothelial cell antibodies in patients with connective tissue disease by flow cytometry and their relation to endothelial cell activation[J].Physiol Res,2002,51(6):613.
  • 7Youinou P, Jamin C. The miscellany of anti-endo- thelial cell autoantibodies[J]. Isr Med Assoc J, 2012, 14 (2): 119-120.
  • 8Alard JE, Hillion S, Guillevin L, et al. Autoanti- bodies to endothelial cell surface ATP synthase, the endogenous receptor for hsp60, might play a patho- genic role in vasculatides[J]. I Plos One, 2011, 6 (2) :e14654.
  • 9DCruz DP, Houssiau FA,Ramirez G, et al. Anti- bodies to endothelial cells in systemic lupus erythe- matosus., a potential marker for nephritis and ascul- itis[J]. Clin Exp Immunol, 1991, 85 (2): 254-261.
  • 10Mehrani T, Petri M. Association of IgA Anti-beta2 glycoprotein I with clinical and laboratory manifes- tations of systemic lupus erythematosus [J]. J Rheumatol, 2011,38(1): 64-68.

引证文献3

二级引证文献14

中国全科医学
2008年 第4期

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