不同DNA倍体鼻咽癌的CT特征

CT characteristics of nasopharyngeal carcinoma with various DNA ploid

目的：从ＣＴ上探讨不同ＤＮＡ倍体的鼻咽癌（ＮＰＣ）的发展规律。材料与方法：搜集４６例ＮＰＣ，采用流式细胞仪（ＦＣＭ）对癌细胞核ＤＮＡ进行检测，发现二倍体肿瘤（ＤＴ）６例，近二倍体肿瘤（ｎＤＴ）１３例，非整倍体肿瘤（ＡＴ）２７例，将它们的ＣＴ所见进行比较分析。结果：ＤＴ较ｎＤＴ和ＡＴ更易形成鼻咽腔肿块，６例ＤＴ无一例颅底骨质破坏，以鼻咽腔生长为主；ｎＤＴ和ＡＴ较ＤＴ更倾向于向深部浸润生长，并且破坏颅底骨质机率较高；从ＣＴ所表现的生长方式上看，ｎＤＴ与ＡＴ相似；ＤＴ、ｎＤＴ和ＡＴ的ＮＰＣ颈部淋巴结转移率无差别。结论：ＮＰＣ在ＣＴ所表现的以鼻咽腔生长为主者，其恶性程度较以深部浸润生长为主者要低。

Purpose: To investigate the developement of NPC with various DNA ploid based on CT study. Materials and methods: According to nuclear DNA content measured by Flow Cytometry, 46 cases of NPC were divided into three categories—6 cases with DT, 13 cases with nDT, and 27 cases with AT. Their CT findings were analysed. Results: Cases with DT tended to develope a mass in nasopharyngeal cavity more frequently than NPC with nDT or AT; NPC with DT had no destruction of the skull base and nasopharyngeal mass was the chief finding while NPC with nDT or AT tended to spread to the deeper layers of nasopharynx: with a higher rate of destruction of the skull base. nDT was similar to AT in CT findings; there was no significant difference in rate of neck nodal metastases between DT or nDT and AT. Conclusion: The degree of malignancy of NPC chiefly growing in nasopharyngeal cavity was lower than those primarily spreading to deeper layers of nasopharynx.