脑深部电刺激治疗帕金森病非运动症状的疗效分析

Analysis of curative effect of deep brain stimulation for non-motor symptoms in Parkinson disease

目的探讨脑深部电刺激术(DBS)对帕金森病(PD)非运动症状(NMS)的治疗作用。方法对102例PD病人进行DBS手术,术前及术后1个月进行NMS量表评估。结果PD病人术前出现NMS3￣18项,平均7.1项。NMS评分与病人的Hoehn-Yahr分级明显相关(相关系数r=0.49,P<0.01)。术后1个月频数明显下降的NMS是:疼痛、感觉异常、失眠、多梦,其他NMS频数手术前后无明显差异。结论PD病人均具有NMS,出现在PD病程的各个时期。随着疾病的进展,PD病人平均NMS评分明显提高。DBS手术短期内可以改善NMS中的疼痛、感觉异常、失眠、多梦等症状,长期疗效尚待观察。

Objective To evaluate the effects of deep brain stimulation （DBS） on non-motor symptoms （NMS） in Parkinson disease （PD）. Methods One hundred and two PD patients received DBS. The NMS questionnaire was used to assess the range of NMS before and 1 month after operation. Results Before the operation, the NMS of the PD patients were of 3-8 items, average 7.1 ones. There was a significant association of NMS score in PD patients with Hoehn-Yahr stage （r=0.49, P 〈0.01）. One month after operation, four items of NMS （pain, paraesthesia, insomnia, vivid dreams） were significantly less than before operation. Other NMS showed no difference between pre-operation and post-operation. Condusion NMS can be observed in all PD patients at all disease stages and correlates to the disease progression. The DBS may improve several items of NMS, such as pain, paraesthesia, insomnia, and vivid dreams in short-term follow up and long-term efficacy remains to be observed.