摘要
与市售片(A)比较研制出贝诺酯(SAPA)胶囊剂(E),将主药与表面活性剂混合研磨提高生物利用度。以表面活性剂溶液作溶出介质浆法测定溶出度。高效液相色谱法测定SAPA在血浆中的代谢物水杨酸(SA)和扑热息痛(PA)的浓度,并对SA血浓进行药动学及生物利用度分析。
The benorylate capsules(E) were developed by triturating the material drug with the surfactant, with the purpose of improving the bioavailability compared with the tablets(A). The dissolution rate in vitro was determined by paddle method and surfactant solution medium. The plasma concentration of hydrolyzates which are salicylic acid(SA) and paracetamol (PA) from benorylated in vivo were measured by HPLC. The pharmacokinetics and bioavailability of the prepared capsules E and tablets A were studied.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1997年第3期146-149,共4页
Journal of China Pharmaceutical University
关键词
扑炎痛
表面活性剂
贝诺酯
胶囊
药物动力学
Benorylate
Surfactant
Salicylic acid
Paracetamol
Pharmacokinetics
