两种高脂饲料致鹌鹑动脉粥样硬化病变的比较

Comparasion of Atherosclerosis Formation Induced by Two Kinds of Rich-fat Diets in Quails

持续用高脂Ⅰ、高脂Ⅱ饲料喂养鹌鹑7周后,血清TC、TG、LDL-C、VLDL-C和AI明显升高,HDL-C、HDL_2-C、HDL_3-C及HDL-C/TC和HDL_2-C/HDL_3-C值明显降低。动脉壁TG、TC、CE、MDA含量及CE/TC值均明显升高,而且,主动脉内膜形成了明显的动脉粥样硬化斑块,病理检查表明:高脂Ⅱ组较高脂Ⅰ组的病变程度更高。吉非罗齐(50,100mg/kg)能明显改善高脂饲料引起的鹌鹑血脂紊乱,减少胆固醇及其酯在动脉壁的沉积,抑制动脉粥样硬化。

60 male Korean quails were divided into 5 groups at random. Group I: on stock diet; Group II:on rich-fat diet I; Group III: on rich-fat diet II ; Group IV: on, rich-fat diet II + Gem-fibrozil (50 mg/kg/d, po) ; Group V: on rich-fat diet II + Gemfibrozil (100 mg/kg/d, po). At the end of 7 weeks, the serum TC, TG, LDL-C, VLDL-C and the index Al increased and HDL-C, HDL2-C, HDL3-C, HDL-C/TC and HDL2-C/HDL:t-C reduced significantly. In group II and group III, the aorfic TG, TC, CE, MDA and CE/TC also increased markedly. There was more obvious atheromatous plaque in aortic walls in group III than in group II. Gemfibrozil could improve the disorder of serum lipid and inhibit the deposition of cholesterol and its ester in aortic wall. Thus, it could prevent the formation of atherosclerosis.