急性胰腺炎由水肿型向坏死型转化时血液流变学的变化

Effect of haemorrheological changes on the transition of edematous pancreatitis to necrosis

目的:观察急性胰腺炎由水肿型向坏死型转化时的血液流变学变化.方法:将188只Wistar大鼠分成六组作胰组织学、胰微循环体视学、酶学和血液流变学观察.结果:胰管梗阻伴胰高分泌状态可致急性水肿性胰腺炎;胰管梗阻时给予DX_(110)致血液流变学改变伴胰微循环障碍但无胰腺坏死;胰管梗阻伴胰高分泌状态并给予DX_(110)导致急性坏死性胰腺炎并伴有明显血液流变学改变和胰微循环障碍.结论:血液粘度和红细胞聚集倾向增大伴红细胞钱串形成及红细胞变形性的降低是造成胰微循环紊乱的原因,并在急性胰腺炎由水肿型向坏死型转化中起重要作用.

One hundred and eighty-eight Wistar rats were evaluated by measurement of haemorrheolo-gical and stereological analysis of pancreatic microvas-culature. The results showed that PDO with hyper-secretion could induce edematous pancreatitis and that PDO with DX110 could induce haemorrheological alterations with pancreatic microcirculatory disturbances whthout pancreatic necrosis , PDO with hypersecretion and DX110 injection induced ANP with obviously haemorrheological changes and pancreatic microcirculatory disturbances. The authors demonstrated that the increased blood viscosity, red blood cell aggregation with rouleaux formation, and decreased erythrocyte de-formability were responsible for pancreatic microcircu-latory disturbances and played an important role in the transition of edematous pancreatitis to necrosis.