氯氮平对超敏C反应蛋白及糖脂代谢的影响

Effect of clozapine on high-sensitivity C-reactive protein and metabolism of glucose and lipid

目的:探讨氯氮平对精神分裂症患者超敏C反应蛋白(hs-CRP)以及糖、脂代谢的影响。方法:对30例服用氯氮平治疗的精神分裂症患者(患者组)作hs-CRP、空腹血糖、三酰甘油、胆固醇、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)检测,于治疗前、治疗第4、8、12周各检测1次。并与30名健康者(对照组)进行比较。结果:治疗前患者组和对照组糖脂各值差异无显著性。在治疗第4、8、12周的hs-CRP,第12周的空腹血糖、三酰甘油、胆固醇、LDL、ApoB比治疗前明显升高;治疗第12周的HDL、ApoA1比治疗前明显下降;hs-CRP与空腹血糖、三酰甘油、胆固醇以及氯氮平剂量呈正相关。结论:氯氮平对hs-CRP、糖脂代谢均会产生影响,氯氮平导致代谢综合征可能与hs-CRP有关。

Objective：To explore, the effect of elozapine on high-sensitivity C-reactive protein （hs-CRP） and metabolism of glucose and lipids in patients with schizophrenia. Method： Hs-CRP, fasting plasma glucose, triglye-eride, cholesterol, high density lipoprotein cholesterol （HDL）, low density lipoprotein cholesterol （LDL）, apoprotein A1 （ApoA1） and apoprotein B （ApoB） were measured in thirty patients with schizophrenia treated with clozapine （patient group） before and after treatment 4,8,12 weeks and in thirty healthy controls （control group）. Results：There were no significant difference between the two groups for all indices above before treatment. For patients with schizophrenia,hs-CRP at 4,8 and 12 weeks increased obviously compared with that before treatment. Fasting plasma glucose, triglyeeride, cholesterol, LDL, apoB at 12 weeks increased significandy, and HDL and ApoA1 at 12 weeks lowed significantly than those at baseline. The level of hs-CRP was positively correlated with fasting plasma glucose, triglyceride, cholesterol and dosage of clozapine. Condusion： Clozapine has effects on hs-CRP and metabolism of glucose and lipid. Metabolism syndrome induced by clozapine may relate to hs-CRP.