摘要
对包括慢性肝炎、肝炎肝硬变和原发性肝癌在内的１００例慢性ＨＢＶ感染者作了ＨＢ－ｓＡｇ亚型分析。结果显示，在这组病例中ａｄｒ亚型占６１％，ａｄｗ占３３％，ａｙｒ占２％，ａｄｗｒ占４％。ａｄｒ亚型有随年龄增长更占优势的趋向。ａｄｒ和ａｄｗｒ亚型感染者ＨＢｓＡｇ滴度较ａｄｗ组显著增高，且ｅ抗原阳性率亦较高。上述发现提示，具有ａｄｒ和ａｄｗｒ亚型的ＨＢＶ株可能具有较强的复制活性，不易被清除，从而导致受感染者病程迁延。
HBsAg subtypes were analysed in 100 patients with chronic HBV infection including chronic hepatitis, hepatitis liver cirrhosis and primary hepatocellular carcinoma. The results showed that among these patients the distributions of HBsAg subtypes were adr(61%),adw(33%),ayr(2%)and adwr(4%). There seems a tendency of HBsAg/adr gradually predominating over HBsAg/adw with increasing age. Patients with HBsAg/adr and HBsAg/adwr had HBsAg titres significantly higher than those with HBsAg/adw and also had rather high positive prevalence of HBeAg. These findings sugges that HBV strains with HBsAg/adr and HBsAg/adwr may possess higher replicative activities and hard to eradicate and consequently result in persistence of HBV infection.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1997年第2期115-118,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
日本文部省国际学术研究基金
关键词
乙型肝炎病毒
表面抗原
亚型
慢性肝炎
HBsAg
subtype
chronic hepatitis
liver cirrhosis
primary hepatocellular carcinoma
