广东省脂肪肝危险因素1：1配对病例对照研究

A 1︰1 MATCHED CASE-CONTROL STUDY ON THE RISK FACTORS OF FATTY LIVER IN GENERAL PEOPLE IN GUANGDONG PROVINCE

[目的]研究普通人群脂肪肝的病因。[方法]采用现场1∶1配对的方法,在现场脂肪肝患病率调查的过程中,每收集1例病例同时选择性别相同、年龄相差不到5岁、居住在同一街道未患脂肪肝的为对照,共405对。[结果]单因素分析结果显示超重和肥胖、高血压、高脂血症(高甘油三酯、高胆固醇和混合高脂)、空腹血糖升高、文化程度、饮酒过量、腰臀比和腰围以及性格和饮豆浆/奶与脂肪肝的患病有关,多因素条件Logistic回归模型进行筛选后显示体重超重和肥胖、高血压、高甘油三酯血症、空腹血糖升高、腰臀比超标以及每周饮酒折含乙醇量超过40g可能是脂肪肝独立的危险因子,而文化程度较高、每天饮豆浆/奶250ml以上可能是脂肪肝患病的独立保护因子。[结论]脂肪肝是一多因性疾病,主要与生活方式和多元代谢紊乱有关。

[Objective] To investigate the risk factors of fatty liver among the general people. [ Methods] By matched 1： 1 ease eontrol study, when we recruited a ease with fatty liver during the prevalence survey performed, a resident without fatty liVer who matched for the ease for sex and age （within 5 years） was collected as control, and a total of 405 controls were colleeted, [Results] Univariate analysis demonstrated that factors such as body mass index （BMI）, high blood pressure, triglyc eride （TG）, total cholesterol （TC）, mixed hyperlipidemia, fasting serum glucose, education level, alcohol-abuse, waist cireumference （WC）, waist hip ratio （WHR）, personal character and soybean milk/milk drinking revealed signifieanfly association with fatty liver. Conditional Logistic multivariate analysis showed that BMI, high blood pressure, TC, fasting serum glucose, WHR, alcohol-abuse were independent risk factors of fatty liver, while high educational level, soybean milk/milk drinking more than 250ml every, day were independent protective factors of fatty liver. [ Conclusion] Fatty liver is a disease with multi-factors, which is associated with life style and muti-metabolie disorders.