充血性心力衰竭与血清肿瘤坏死因子和白介素-6及其受体水平的关系

Study on Levels of Serum Tumor Necrosis Factor and Interleukin-6 in Patients with Congestive Heart Failure

目的探讨血清肿瘤坏死因子和白介素-6及其受体水平在充血性心力衰竭发生、发展中的作用。方法测定了86例充血性心力衰竭患者及30例正常健康成人的血清肿瘤坏死因子（TNFa）、白介素-6及其受体水平。结果充血性心力衰竭患者血清TNFa、IL-6及其受体水平较正常对照组明显升高（P〈0．001），且随着心功能的恶化逐渐升高，心功能Ⅰ-Ⅳ级各亚组间差别有显著统计学意义（P〈0．01）。结论只有生物活性的细胞因子在充血性心力衰竭的发生、发展中起重要作用。

Objective To study the levels of serum tumor necrosis factor-alpha （TNF-alpha） , interleukin-6 （ IL-6 ） and their receptors in congestive heart failure （CHF）. Methods We measured the levels of TNF-alpha and IL-6 in 86 patients with CHF and 30 healthy controls. Results The levels of TNF-alpha, IL-6 and their receptors were noticeable higher in the patients with CHF than in the controls （P 〈 0. 001 ）. They rose gradually with the deterioration of cardiac function, and there were marked differences among the subgroups of various cardiac function （ P 〈 0.01 ）. Conclusion Cytokines with biological activity may play roles in the pathogenesis of CHF.