幽门螺杆菌感染治疗药物经济学分析

Pharmacoeconomic Analysis of Treatment of Helicobacter Pylori Infection in Community

目的从药物经济学角度出发,分析4种不同方案治疗幽门螺杆菌感染,为临床合理用药提供参考。方法对118例幽门螺杆菌阳性病人给予4种不同治疗方案,A组:奥关拉唑+阿莫两林+克拉霉素,疗程1周;B组:奥美拉唑+阿莫西林+甲硝唑,疗程1周;C组:奥美拉唑+甲硝唑+克拉霉素,疗程1周;D组:雷尼替丁+阿莫西林+甲硝唑,疗程2周。采用效果观察和成本-效果分析法进行药物经济学评价。结果A、B、C、D 4种方案有效率分别为95.6%、90.2%、92.2%、87.3%,各组间差异无显著性。1个疗程人均药物费用分别为201.6元、50.82元、166.32元、78.12元;有效率每增1个百分点所需费用分别为2.09元、0.56元、1.79元、0.90元。结论B方案费用最低,为社区治疗幽门螺杆菌的首选方案。

Objective To analyze 4 different treatment methods of Helicobacter Pylori Infection （H, pylori infection） and provide reference for clinical tea.tunable using of medicine. Methods 118 patients with H. pylori infection were randomly divided into fnur groups. Group A was treated with Omeprazole ＋ Amnxicillin ＋ Clarithromycin for one week; Group B was treated with Omeprazole ＋ Amoxicillin ＋ Metronidazole for one week; Group C was treated with Omeprazole ＋ Metronidazole ＋ Clarithromycin for one week; Group D was treated with ＇Ranitidine ＋ Amoxicillin ＋ Metronidazole for two week. Effect observation and cost-effectiveness analysis were used for pharmacoeconomic evaluation. Results Tne effective rates of Group A, Group B, Group C, Group D were 95. 6%, 90. 2%, 92. 2%, 87. 3% respectively, with no significant differences （P 〉 0. 05）The average drug costs per person for one therapeutic course were 201. 6 yuan, 50. 82 yuan, 166. 32 yuan and 78. 12 wan, respectively; anti increase of 1% effective rate test 2. 09 yuan, 0. 56 yuan, 1. 76 yuan, 0. 90 yuan respectively. Conclusions The lowest cost scheme was scheme B; it should be the first chosen scheme in treating H. pylori infection in community.