前白蛋白在老年COPD患者急性加重期中的临床意义

Study on the clinical significance of serum prealbumin in acute exacerbation of chronic obstructive pulmonary disease (COPD) patients

目的探讨血清前白蛋白水平(PA)在老年COPD患者急性加重期中的临床意义。方法选取入院治疗的60岁以上老年慢性阻塞性疾病(COPD)急性加重期患者100例,分为血清前白蛋白正常组(PA>=200mg/dl),前白蛋白减低组(PA<200mg/dl),比较两组患者间血白细胞计数,C反应蛋白,血气酸碱度,氧分压,二氧化碳分压的差别,并分析PA与CRP,PO2,PCO2之间的关系。结果血清前白蛋白正常组与血清前白蛋白异常组CRP,PO2之间存在显著的差异(P<0.01),两组白细胞计数,PH,PCO2无明显差异。结论血清前白蛋白可以作为预测COPD患者急性加重期感染的一项指标,同时可以反映患者肺氧合功能。

Objective Study on the clinical significance of seram prealbumin in acute exacerbation of chronic obstructive pulmonary disease（COPD） patients. Methods We selected 100 patients of COPD more than sixty in acute exacerbation and they were devided into two groups, PA normal group（ PA 〉 = 200 mg/dl）and PA reduced group（ PA 〈 200 mg/dl ）. We investigated the difference of blood WBC, CRP,PH,PO2 ,PCO2 between two groups and analyzed the relations between PA with WBC ,CRP,PH ,PO2 ,PCO2. Results There was significant difference in CRP and PO2 betwwen two groups（P 〈0.01 ） while no difference was found in WBC,PH and PCO2. Conclusions PA in blood serum can work as an index to predict infection in acute exacerbation of COPD patients and also can reflect oxygenation functions.