大肠癌组织中胃泌素表达的临床意义

Clinical significance of gastrin expression in colorectal cancerous tissue

目的：研究大肠癌组织中胃泌素表达，旨在探讨胃泌素在大肠癌发生和发展过程中的作用及临床意义.方法：采用免疫组化及免疫电镜技术检测53例大肠癌组织中胃泌素表达。结果：大肠癌组织胃泌素阳性率为56．6%（30/53）；高分化腺癌阳性率为90％（9／10），明显高于中分化腺癌（48.4％，16／33）和低分化腺癌（25％，1／4）。胃泌素表达强度与分化程度有关。胃泌素阳性胶体金颗粒见于癌细胞内不同电子密度分泌颗粒中、癌细胞间隙或微绒毛膜表面．结论：大肠癌细胞形成胃泌素。大肠癌组织胃泌素阳性表达是其分化良好标记。

Objectives :To study the gastrin expression in colorectal cancerous tissue and its clinical significance .Methods:Detection of gastrin expression in 53 cases of colorectal Results :The positive rate of gastrin in colorectal carcinomatous tissue is 56.6% ,it is highest in poorly differentiated ones(25%,1/4),The intensity of staining was correlated with tumor different electroduense secretory granules of cancer cells ,in the intercellualar space or in the surfacemembrane microvilli Conclusions:The gastrin is formed and released by gastrin secretory granulesin colorectal cancer cells,and positive expresses of gastrin in colorectal cancerous tissue serves as a market of well differentiated ones .