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Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation 被引量：1

Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation
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摘要 Antidepressant duloxetine （1） was prepared via asymmetric transfer hydrogenation of 3-（dimethylamino）-1-（thiophen-2- yl）propan-1-one （3）. The Ru（Ⅱ）, Rh（Ⅲ） and Ir（Ⅲ） complexes of several chiral ligands were examined as the catalyst and （S,S）-N-tosyl-1,2-diphenyl ethylenediamine （TsDPEN）-Ru（Ⅱ） complex was found to provide good yield and excellent enantioselectivity. 2007 Ming Yan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. Antidepressant duloxetine （1） was prepared via asymmetric transfer hydrogenation of 3-（dimethylamino）-1-（thiophen-2- yl）propan-1-one （3）. The Ru（Ⅱ）, Rh（Ⅲ） and Ir（Ⅲ） complexes of several chiral ligands were examined as the catalyst and （S,S）-N-tosyl-1,2-diphenyl ethylenediamine （TsDPEN）-Ru（Ⅱ） complex was found to provide good yield and excellent enantioselectivity. 2007 Ming Yan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
作者 Shan Zhen He Xue Ming Li Jia Dai Ming Yan
机构地区 The Industrial Institute of Fine Chemicals and Synthetic Drugs Guangdong Provincial People＇s Hospital
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第1期23-25,共3页 中国化学快报（英文版）
基金 We thank the National Natural Science Foundation of China （No. 20472061）；Guangzhou Bureau of Science and Technology for financial support of this study.
关键词 DULOXETINE SYNTHESIS Asymmetric transfer hydrogenation TsDPEN-Ru（Ⅱ） complex Duloxetine Synthesis Asymmetric transfer hydrogenation TsDPEN-Ru（Ⅱ） complex
分类号 R971 [医药卫生—药品] R914 [医药卫生—药物化学]
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参考文献11

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同被引文献21

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Chinese Chemical Letters
2008年 第1期

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