Features of trinucleotide repeat instability in vivo

不稳定的重复与癌症的各种各样的类型被联系并且在超过 40 neurodegenerative 混乱被含有。三核甙酸重复位于染色体的非编码、编码的区域。细菌，酵母，老鼠和人的研究帮助了解开三核甙酸的机制的一些特征扩大。包括三核甙酸重复的循环脱氧核糖核酸结构在复制或修理期间被处理产生删除或扩大。大多数体内数据与扩大和删除由不同机制在发生的一个模型一致。在哺乳动物，微卫星不稳定性是复杂的并且看起来被影响由基因， epigenetic 和发展因素。

Unstable repeats are associated with various types of cancer and have been implicated in more than 40 neurode-generative disorders. Trinucleotide repeats are located in non-coding and coding regions of the genome. Studies of bacteria, yeast, mice and man have helped to unravel some features of the mechanism of trinucleotide expansion. Looped DNA structures comprising trinucleotide repeats are processed during replication and/or repair to generate deletions or expansions. Most in vivo data are consistent with a model in which expansion and deletion occur by different mechanisms. In mammals, microsatellite instability is complex and appears to be influenced by genetic, epigenetic and developmental factors.