脑梗塞患者血LP(a)、ox-LDL、D-D、Fbg含量的研究

Study on concentrations of LP(a) OX-LDL D-D Fbg in plasma of patients With cerebral infarction

本研究按不同年龄组分别测定了110例正常人和123例脑梗塞患者急性期和恢复期血中LP（a）、ox-LDL、D-D、Fbg的含量，结果显示：脑梗塞患者血中LP（a）、ox-LDL、D-D、Fbg较正常对照组显著升高（P＜0．01），并且LP（a）、ox-LDL、D-D在脑梗塞人血中呈正相关（r=0.876，P＜0．05）。正常人D-D的含量随年龄的增高有增长趋势，低年龄组与高年龄组有显著性差异（q=4．82，P＜0．01）。LP（a）、OX-LDL、Fbg含量各年龄组无差异（P＞0．05）。D-D随年龄增长塔高明显（R=0．596P＜0．01）并且与梗塞面积正相关（r=0．819，P＜0．01），而LP（a）、OX-LDL、Fbg与梗塞面积无关。同时发现D-D在脑梗塞恢复期明显降低（P＜0．05），证实了脑梗塞急性期确实存在高凝状态和内源性纤溶功能活跃。

In this study,plasma Lp(a) OX-LDL D-D and Fbg were observed inthe 123 patients with acute stage and restoration stage cerebral infarction and 110 age-and sex-matched healthy persons. The result showed that the concentrations of Lp(a)OX-LDL D-D and Fbg in cerebral infarction patients were significient higher than that of the normal control group (P＜0. 01) and the Lp(a) OX-LDL D-D concentrations in plasma had positive correlation (r=0.876 P＜0. 05 ). The D-D concentrations in healthy persons showed a much further increase as the age added.There was significant difference of D-D concentrations between the elder group and the younger group (q= 4. 82 p＜0. 01). There was no difference of Lp(a) OX-LDL Fbg concentrations between different age groups. The D-D concentrations significantly increased as the age added (r=0. 596 P＜0. 01) and had positive correlation to infarction volume(r=0. 596 P＜0. 01) and had positive correlation to infarction volume (r=0. 819 P＜0.01 ). The D-D concentrations also increased in patients with lucunar infarction and the more the infarction volume was, the more the D-D concentrations increased. The concentrations of Lp (a) OX - LDL and Fbg had no corretation to infarction volume and the infarction stage. D-D was significantly decreased in the restoration stage (P＜0. 05). Thisstudy proved that there was a hypercoagulability and active endogeneuisfibrinolysis action in active cerebral infarction.