摘要
芦氟沙星（Ｒｕｆｌｏｘａｃｉｎ）是氟喹诺酮类抗菌药物，由于它在体内有高效、广谱、长效和口服吸收良好等特点，我们在保留芦氟沙星母核基本骨架的基础上进行结构修饰，合成了１２个新化合物。体外抑菌试验发现随着１０位边链的极性增大，对革兰氏阴性（Ｇ－）菌的抗菌活性增强，而对革兰氏阳性（Ｇ＋）菌活性则变化不大。
Twelve new analogues of new tricyclic rufloxacin were prepared and their MIC were evaluated against thirteen kinds of bacteria. As a result of these studies: the polarity of C 10 side chain was found to exert greater positive effect on G - than on G + bactria.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第5期347-352,共6页
Acta Pharmaceutica Sinica
