2-氨基-4,6-二甲氧基嘧啶新合成方法

A novel synthesis of 2-Amino-4, 6-dimethoxypyrimidine

本文利用硝酸胍和丙二酸二乙酯为起始原料,经环合及甲氧基化两步反应得到除草剂啶嘧磺隆的中间体:2-氨基-4,6-二甲氧基嘧啶(Ⅰ).反应条件温和,总产率较高,达到83%.

The intermediate of flazasulfuron weedicide, 2-amino-4,6-dimethoxypyrimidine （ Ⅰ ） is conveniently obtained by treating 2-amino-4, 6-dihydroxypyrimidine （ Ⅱ ） with diazomethane at 20 ℃ for 24h. The reaction is mild and the overall yield is 83%.