阻断转化生长因子-β信号通路在肿瘤治疗中的应用

Blockade of transforming growth factor beta signaling in suppressing tumors

转化生长因子-β（TGF—β）通过诱导上皮间-充质转化、促进血管发生及免疫逃逸等机制参与肿瘤的发生发展。从受体、配体及下游信号转导系统等不同水平阻断TGF—β信号转导通路，为肿瘤的免疫治疗提供了新的思路。

Evidence supports a central role for transforming growth factor beta （TGF-β）in tumorigenesis and tumor progression. TGF- β has been shown to act as an oncogenic cytokine through induction of epithelial- mesenchymal transition, angiogenesis, and immune escape. Blockade of TGF- β signaling by modulating it＇ s receptor, ligand and downstream signal transduction system may be therapeutically useful for malignant tumors.