Rho蛋白及其抑制剂

Rho protein and its inhibitors

Rho蛋白在调节肿瘤细胞功能方面起着关键作用，包括肿瘤细胞的恶性转化、细胞的移动、细胞周期和细胞凋亡，其中每个环节对肿瘤细胞的发生和进展都极为重要。特异的Rho蛋白抑制剂可以逆转肿瘤细胞的恶性表型，从而达到抗肿瘤治疗的目的。

Rho protein plays a pivotal role in the regulation of tumor cells functions,such as malignant transformation,cell motility,cell cycle and cell apoptosis. Each of these functions is of great importance for the development and progression of tumor. Therefore, specific inhibitors of Rho protein can reverse the tumor cells malignant phenotypes and treat cancers.