Notch信号通路与脑肿瘤

Notch signaling pathway and brain tumor

Notch信号通路作为一个对细胞的生长发育具有广泛多样化影响的信号途径，也与肿瘤的发生、发展相关。对于不同的肿瘤或同一肿瘤的不同级别、不同发展阶段Notch信号通路可能具有不同作用。Notch信号在一些脑肿瘤（脑胶质瘤、髓母细胞瘤、神经母细胞瘤、脑膜瘤）中异常表达，且参与这些脑肿瘤的发生、发展。

The Notch pathway plays an integral role in determining cell fates in ceils growth and development. Also, this pathway has versatile effects in tumorigenesis depending on the tumor type, grade and phase. In addition, Ntch pathway is often aberrant in some brain tumors such as tumor ghoma, medulloblastoma, neuroblastoma and meningioma, Notch pathway is involved in tumorigenesis and development of these tumors. Modulation of Notch signaling may be therapeutically useful in these malignant tumors.