纤维连接蛋白、层黏连蛋白、细胞外基质金属蛋白酶诱导因子在食管癌的表达

Expression of fibronecfin, laminin and extracellular matrix metalloproteinase inducer in esophageal Carcinoma

目的研究纤维连接蛋白（FN）、层黏连蛋白（LN）、细胞外基质金属蛋白酶诱导因子（EMMPRIN）在食管癌的表达，探讨其临床意义。方法采用免疫组织化学法对87例食管癌组织、30例正常食管组织、20例不典型增生食管组织进行FN、LN、EMMPRIN检测。结果正常食管组织基底膜FN、LN染色呈连续线状；低分化癌巢周围基底膜FN、LN染色表现为碎片状；FN、LN表达与食管癌病理分级、淋巴结转移有关；EMMPRIN的弱阳性表达与食管癌淋巴结转移有关，强阳性表达与食管癌的病理分级、临床分期和淋巴结转移有关。结论FN、LN、EMMPRIN表达可作为评价食管癌侵袭性及恶性程度的有用指标。

Objective To study the expression and clinical significance of fibronectin （FN）, laminin （LN） and extracellular matrix metalloproteinase inducer（EMMPRIN） in esophageal carcinoma. Methods Immunohistochemical staining was used to detected the expression of FN, LN and EMMPRIN in 87 esophageal carcinoma tissues,30 normal esophageal tissues and 20 dysplasia of esophageal tissues. Results In normal esophageal tissues, FN and LN in basement membranes were continuous linear;in poorly differentiated carcinomas, FN and LN in basement membranes were fragmentary. There were correlations between the expression of FN ,LN and pathology grade, lymph node metastasis of esophageal carcinoma; there was correlation between the weakly positive expression of EMMPRIN and lymph node metastasis of esophageal carcinoma, there were correlations between the intensely positive expression of EMMPRIN and pathology grade, clinical stage and lymph node metastasis of esophageal carcinoma. Conclusion FN, LN and EMMPRIN can be used as helpful markers to evaluate the invasive ability and malignant degree of esophageal carcinoma.