脓毒症动物模型的研究进展

Advances in animal models of sepsis

脓毒症以其高发病率和高病死率成为世界医学界瞩目的焦点。长期以来，为研究其发病过程和探讨其复杂的发病机制，建立了多种动物模型。本文从模型的动物选择、建立、评价及不足等方面综述了脓毒症动物模型的研究现况，以期找到能忠实再现人类疾病演变过程的合理动物模型。

Sepsis with its rising incidence and high mortality is still a major challenge in worldwide medicine. For a long time, in order to study the process and the pothogenesy of sepsis, several animal models have been set up. This review summarized the common animal sepsis models in several ways, such as animal selection, models foundation, comment and deficient, and aimed and to find the most suitable animal models that can reflect the process of sepsis in patients.