观察大剂量巴曲酶对急性脑梗死患者的疗效

Observation on the therapeutic effects of Batroxobin against acute cerebral infarction with the high dosage

目的:观察大剂量巴曲酶注射液在我院神经内科治疗急性脑梗死患者的疗效。方法:通常应用的巴曲酶注射液的总剂量是20BU(Batroxobinunit)。而在我院应用的总剂量是常规剂量的2倍,即40BU,每日1次,共分4次静脉滴注。第1次20BU,第2次10BU,第3次5BU,第4次5BU。每次使用前,加入生理盐水250ml稀释,静脉点滴1h以上。结果:治疗组的总有效率为92%,对照组的总有效率为56%,两者比较差异有统计学意义(P<0.05)。结论:用巴曲酶治疗急性脑梗死效果较好,没有发现出血倾向及过敏反应,对血小板无影响。

Objective：To observe the therapeutic effects of Batroxobin with high dosage against acute cerebral infarction in nerve medicine of our hospital.Methods：Generally the total dosage was 20 Batroxobin unit（BU）. But in our hospital, the dosage was two times of it. The patient should be injected with Batroxobin once a day, altogether four times. The first dosage was 20 BU, the second was 10 BU, the third was 5 BU, the last was 5 BU. Before using,it should be diluted with 250 ml of physiological saline and the diluted solution should be injected by intravenous infusion for more than a hour. Results： Total effective rate of the treatment group was 92% ,which was superior to the contrast group of 56%（P〈0.05）. Conclusion：The curative effect is better with high amount of Batroxobin, and it hasn＇ t been discovered tendency of bleed- ing,allergic reaction and the influence to the function of platelet.