创伤性颅脑损伤国内研究进展

Recent Developments of Studies on Traumatic Brain Injury in China (review)

创伤性颅脑损伤已成为发达国家青少年伤病致死的首位病因;我国的颅脑伤发生率和因颅脑伤致残、致死的伤员也逐年增加。近10年来,我国有条件的神经科开始逐渐重视颅脑外伤的基础研究和临床防治应用研究,并取得一定进展,但仍存在一些问题和不足,特别是实验研究条件与国际先进水平仍有较大差距。本文作者系统回顾了近年来国内有关创伤性颅脑损伤的最新研究进展,主要是外伤后的并发症、康复治疗,以及预后的研究进展,也包括基础的病理机制、动物模型,以及神经保护和修复再生技术的相关研究进展,并对比了国内外研究方向和研究水平的差异。

In developed countries, traumatic brain injury （TBI） has been the first cause of disability and mortality in adolescents, and in China, the incidence of TBI and the amount of disable or died patients after TBI increased with years. During the past decades, much more emphasis were paid on fundamental and clinical researches on TBI in China, and much developments have been made. But there are a lot of problems and shortness in these researches and clinical treatments of TBI, especially the conditions of research get behind of advanced world levels. In this review, the recent developments of studies on TBI were summarized, mainly the researches of complications, rehabilitation and outcome after TBI, also including the researches of fundamental pathological mechanism, animal pattern, neural protect and reparative regeneration technique of TBI, as well as the difference of trend and level between researches in China and foreign countries.