摘要
目的研究天麻素对偏头痛大鼠的预防作用及对脑组织中单胺类神经递质的影响。方法天麻素预防给药5d,于第5天给药后皮下注射硝酸甘油复制偏头痛模型,并观察其耳红、挠头次数等行为学指标,采用高效液相色谱法测定各组大鼠脑组织中5-羟色胺、去甲肾上腺素和多巴胺的含量变化。结果天麻素对偏头痛大鼠耳红、挠头等行为具有干预作用,能明显升高大鼠脑组织中5-羟色胺、多巴胺及去甲肾上腺素的含量。结论天麻素能预防偏头痛发作,这种作用可能与调节机体单胺类神经递质的释放和代谢机制得以恢复,进而改善脑及血管的功能障碍有关。
Objective To research the effects and mechanism of gastrodin against migraine and on single amine neurotransmitter. Methods The model of nitroglycerin migraine was made after rat treated by gastrodin for 5 days, the time points of ear rubescence and the times of scratch head were observed to take as evaluation index of pharmacodynandc action, the concentration of 5-HT, NE and DA were measured in the brain with HPLC. Results Gastrodin could obviously prevent the attack of migraine and increase the concentration of S-HT, DA and NE in the brain. Conclusions The effects of gastrodin against migraine is related with the concentration of 5-HT, DA and NE in the brain, gastrodin can regulate neurosystematic functions and enhance the secretion and metabolism of neurotransmitters.
出处
《中国中医药信息杂志》
CAS
CSCD
2008年第2期32-33,共2页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金资助(30600828)
