不同预处理方法对活血通络水提液超滤工艺的影响

Effect of Pretreatment on Ultra-filtration Membrane Separation of Huoxue Tongluo Extract

目的探讨减压抽滤、低速离心、高速离心、壳聚糖絮凝、活性炭脱色作为前处理方法对活血通络水提液膜过程中通量及膜污染度的影响。方法采用正交实验设计,以芍药苷转移率以及膜污染度等指标考察絮凝条件对膜分离效果的影响,并与其它方法进行比较。结果壳聚糖絮凝前处理法在指标性成分芍药苷的保留率上优于减压抽滤、低速离心、高速离心和活性炭脱色,且膜污染度最小,药液膜通量最大。结论壳聚糖絮凝法是活血通络水提液膜前处理的较适方案,最优絮凝工艺条件为:药液温度50℃,pH=5,1%醋酸壳聚糖用量30mL/L。

Objective To investigate chitosan flocculating and other pretreatments of Huoxue Tongluo extract and their effects on the membrane flux and fouling degree of membrane. Methods Based on the index related to the total sinomenine reserved in liquid and fouling degree of membrane, compared to other pretreatments, discuss the function of chitosan used as flocculation and the effect on membrane separation by orthogonal test. Results The reservation of the total sinomenine was best by means of chitosan flocculation and the smallest fouling degree of membrane was it too, compared with other pretreatments as decompress filtration, high-speed-centrifugation, low-speed-centrifugation and decolored by active carbon. Conclusion Chitosan flocculating is the best pretreatment method of Huoxue Tongluo extract, and the suggested operation condition is that the Huoxue Tongluo extract＇s temperature is 50 ℃, pH=5 and add 1% chitosan 30 mL/L.