冠脉支架术后血浆降钙素基因相关肽水平与支架术后疗效的关系

Relationship between Plasma Level of Calcitonin Gene Related Peptide and Clinical Effect after Coronary Stent Implantation

目的探讨冠状动脉支架术前后血浆降钙素基因相关肽(CGRP)水平对支架术后6个月内心血管事件及再狭窄的相关预测价值。方法对53例冠心病心绞痛患者行冠状动脉支架术治疗,测定术前及术后血浆CGRP水平,并记录术后6个月内心血管事件及再狭窄情况。结果发生心血管事件及再狭窄组CGRP水平明显低于未发生组(166.36±10.18,182.5±11.36,P<0.05);发生心血管事件及再狭窄组糖尿病患者所占比例明显高于未发生组(53%,34%,P<0.01)。结论冠状动脉支架术后血浆CGRP水平相对降低及糖尿病与冠状动脉支架术后心血管事件及再狭窄相关。

Objective To assess the predictive value of plasma level of calcitonin gene related peptide for cardiovascular events and operational stent restenosis after coronary stent implantation in 6 months. Methods Plasma level of CGRP was measured in 53 cases of coronary stent implantation before and after the operation. The cardiovascular events and the stent restenosis were observed and recorded in 6 months after the procedure. Results The plasma level of CGRP was significantly lower in patients with cardiovascular events and stent restenosis（ 166. 36 ± 10. 18 , 182.5 ± 11.36, P 〈 0. 05 ）. There were more often patients with diabetes mellitus in the group of cardiovascular events and stent restenosis than in another group （53% ,34% , P 〈 0.01 ）. Conclusion The plasma level of CGRP and diabetes mellitus have relativity with the cadiovascular events and the stent restenosis after operation.