阿立哌唑治疗精神分裂症的开放性研究

OPEN STUDY ON ARIPIPRAZOLE IN TREATING SCHIZOPHRENIA

目的了解阿立哌唑治疗精神分裂症的疗效及副作用。方法使用阿立哌唑对55例精神分裂症患者进行8周开放式治疗观察，药物剂量范围5～30mg／d；使用PANSS量表、临床疗效总评量表（CGI）评定疗效；以治疗药物副作用量表（TESS）评定药物不良反应。结果55例均完成8周疗程。治疗结束时，显效率为61．8％（34／55），其中临床痊愈30．9％（17／55），显著进步30．9％（17／55），好转23．6％（13／55），无变化14．5％（8／55）。常见的不良反应为：静坐不能、震颤、失眠、心动过速，焦虑、头晕、乏力等，症状轻，不影响治疗。结论阿立哌唑治疗精神分裂症有效、比较安全，使用方便，可作为临床治疗精神分裂症的一种选择。

Objective To explore the curative effects and the side effects of aripiprazole in treating schizophrenia. Methods 8-week observations were made to assess the curative effects of aripiprazole on 55 patients with schizophrenia. All cases were given a dosage of 5-30mg each day. The curative effects were evaluated according to the Clinical Global Impression（CGI） and Positive and Negative Symptoms （PANSS）. The side effects were as- sessed according to the Treatment Emergent Symptoms Scale（TESS）. Results All these cases compleated their courses of treatment. 61.8 % （34/55） of the cases got obvious curative effect, 30.9 % （17/55） got over, 30.9 % （17/55） got significant improvement, 23.6 % （13/55） got rome improvement and 14.5 % （8/55） got no improve- ment. The common side effects were acathisia, tremor, insomnia, tachycardia, anxiety, dizziness and acratia, all of which produce slight effects. Conclusion Apripiprazole can be effectively used to treat schizophrenia.