依达拉奉联合路路通注射液对脑出血急性期临床作用的研究

THE COMBINED USE OF EDARAVONE AND LULUTONG INJECTION TO TREAT CEREBRAL HEMORRHAGE AT THE ACUTE STAGE

目的探讨依达拉奉联合路路通注射液对脑出血急性期的临床作用。方法对照组65例给予20%甘露醇、25%硫酸镁、10%氯化钾、胰岛素、乙酰谷酰胺,静脉滴注,连用2周;治疗组65例在上述治疗基础上,于发病后3 d给予路路通0.25g静脉滴注,1次/d,连用10d;同时于发病后给予依达拉奉30 mg加入生理盐水静滴,2次/d,连用14d。结果治疗组显效率58.46%、有效率96.92%,对照组显效率15.38%、有效率84.62%,显效率治疗组明显优于对照组(P<0.05);水肿平均缩小面积:治疗组明显优于对照组(P<0.05);神经功能缺损评分对照:在治疗3周、4周后,治疗组评分明显优于对照组(P<0.05)。结论依达拉奉和路路通联用,对于脑出血急性期的作用机制,是通过消除自由基,减轻脂质过氧化反应,改善微循环障碍,降低血液粘滞度,从而减轻细胞损伤和脑水肿,改善神经功能,达到临床治疗目的。

Objective To explore the curative effects of the combined use of edaravone and lulutong injection to treat cerebral hemorrhage at the acute stage. Methods In the contrast group,65 cases were given 20% mannitol,25 % magnesium sulfate, 10% potassiumichloride, insulin and acetyl-glutamine for two weeks. In the treatment group, 65 cases were treated with the above-mentioned drugs as well as 0.25g of lulutong injection from the 3rd day of attack,once a day, for 10 days, and then 30mg of edaravone in normal saline was given after the attack,twice a day,for 14 days. Results The obvious rates of clinical effects of the treatment group and the contrast group were 58.46 % and 15.38 % respectively, and the rate of total therapeutic effects were 96.92 % and 84.62 % respectively. The rate of obvious clinical effects was higher in the treatment group （ P 〈 0.05）. The area of hydrops narrowed more in the treatment group （ P 〈 0.05）. The assessment of nervous dysfunction revealed that the scores were higher in the treatment group in the 3rd and 4th week（ P 〈0.05）. Conclusion The combined use of edaravone and lulutong injection can reduce cell injury and cerebral hydrops and can improve the nervous functions by removing free radical, relieving lipid peroxidation and improving the blood viscosity.