核受体介导细胞增殖分化与凋亡的作用机制研究进展

Advance in Study on Nuclear Receptor Mediating Cell Proliferation Differentiation and Apoptosis

核受体是配体依赖性的转录因子,广泛存在于细胞内,主要分为激素类核受体与孤儿核受体。它们与机体的生长发育,细胞的增殖、分化与凋亡,以及体内众多生理、物质代谢及肿瘤形成过程中基因表达的调控有很大关系。现就核受体介导细胞增殖、分化与凋亡的作用机制研究进展做一综述。

Nuclear receptors are intracellular ligand-activated transcription factors including hormones nuclear receptors and orphan nuclear receptors. Nuclear receptors are involved in regulating gene expression in development, cell proliferation differentiation and apoptosis, physiological, substance metabolism and tumor formation. This article reviewed the. advance in study on nuclear receptor mediating cell proliferation differentiatian and apoptosis.