血管内皮细胞TLR2与动脉粥样硬化发展关系的研究进展

Study Progress about the Relationship between TLR2 in Vascular Endothelial Cells and Development of Atherosclerosis

目前,动脉粥样硬化(AS)被认为是一种慢性炎症过程,Toll样受体2(TLR2)通过激活天然免疫,参与特异性免疫应答的启动,促进炎症的发展,在AS中发挥了重要作用。同时在AS发展过程中内皮细胞发生功能障碍,并产生多种细胞因子,促进AS的发生、发展。此外,TLR2与内皮细胞之间存在一定的相互作用,对AS产生影响。

Nowadays, atherosclerosis is considered to be a chronic inflammatory diseaso,TLR2 can participate the initiation of specific immune response, promote the progression of inflammatory,and play an important role in atherosclerotie disease by activating native immmlity. Meanwhile, Endotheliocytes also have functional disturbance during the precess of AS, and can produce many eytokines to promote the genesis and development of AS. Besides, there is somewhat eoaetion between TLR2 and endothelium, which also have some influences on AS.