血管性血友病因子基因多态性与糖尿病血管并发症相关性研究进展

Research Progress of Correlation Between vWF Gene Polymorphism and Diabetic Vascular Complications

血管性血友病因子是血管内皮细胞受损和功能障碍的标志,因其在凝血过程中所发挥的双重作用,使其成为目前研究血栓性疾病发病危险因素的热点。糖尿病血管并发症是糖尿病患者主要的致残、致死原因,遗传因素可能在并发症的发病过程中发挥着重要的作用。近年来,对于血管性血友病因子基因多态性与糖尿病血管并发症是否存在相关性的研究正日益增多,从基因水平研究糖尿病血管并发症的发病机制对于其预防及诊治具有重要的意义。

Von Willebrand factor is the mark of the vessel endothelial cell damaged and dystunction, and its dual function which displays in the hemostasis process makes it become a study hot spot on the risk factor of thrombotic disease at present. Diabetic vascular complications are the main cause of cripples and death of the diabetic patients, and the hereditary factor might play the vital role in the morbidity process of complications. Recently, researches about the correlation between vWF gene polymorphism and diabetic vascular complications are increasing, and the researches about diabetic vascular complications pathogenesis in the gene level will have a great significance to the prevention, diagnosis and treatment of diabetic vascular complications.