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CEACAM1与CD105在子宫内膜癌中的表达及意义 被引量：5

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摘要 目的探讨癌胚抗原相关细胞黏附分子1(CEA-related cell adhesion molecularl,CEACAM1)在子宫内膜癌中的表达和意义及其与CD105(Endoglin)在子宫内膜癌组织中表达的关系。方法采用Elivision plus免疫组化二步法,检测52例子宫内膜癌及22例正常子宫内膜组织中CEACAM1、CD105的表达情况。结果CEACAM1在子宫内膜癌组织与正常子宫内膜组织间的表达差异有显著性(P<0.05),在正常子宫内膜中的表达率比在子宫内膜癌的表达率高,并且随着子宫内膜癌恶性程度的增加表达率减少(P<0.05);CD105在子宫内膜癌中的表达较正常子宫内膜高,并且与子宫内膜癌的手术病理分期和淋巴结转移密切相关。但两者之间无明显相关性。结论CEACAM1是一种肿瘤抑制基因,它的表达减少可能引起子宫内膜癌的发生、发展;CD105是一种新生血管标记物,其标记的肿瘤内微血管计数(MVD)对评估子宫内膜癌恶性程度有重要意义。
作者 王升华 纪新强 高占军
机构地区 青岛大学医学院附属医院妇科
出处 《实用肿瘤学杂志》 CAS 2008年第1期35-37,共3页 Practical Oncology Journal
关键词 子宫内膜癌 CEACAM1 CD105 血管生成
分类号 R737.33 [医药卫生—肿瘤]
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参考文献8

  • 1Wagener C. and Ergun S. Angiogenic Properties of the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 [ J ]. Exp. Cell Res,2000 ; 261 : 19-24
  • 2Volpert O, Luo W, Liu TJ , et al . Inhibition of Prostate Tumor Angiogenesis by the Tumor Suppressor CEACAM1 [ J]. J Biol Chem, 2002 ; 277 (38) :35696-35702
  • 3Kammerer R, Riesenberg R, Weiler C, et al. The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma [ J ]. J Pathol,2004 ; 204 : 258-267
  • 4Cruz PV, Wakai T, Shirai Y, et al. Loss of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Expression Is an Adverse Prognostic Factor in Hepatocellular Carcinoma [ J ]. Cancer, 2005 ; 104:354-360
  • 5Sienel W, Dango S, Woelfle U, et al. Elevated Expression of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 Promotes Progression of Non-Small Cell Lung Cancer[ J]. Clin Cancer Res, 2003 ;9:2260-2266
  • 6Tilki D, Irmak S, Oliveira-Ferrer L. CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer[J]. Oncogene,2006 ; 25 : 4965 4974
  • 7Duff SE, Li CG, Garland JM, et al. CD105 is important for angiogenesis: evidence and potential applications [ J ]. FASEB J, 2003 ; 17,984-992
  • 8Salvesen HB, Gulluoglu MG, Stefansson I, et al. Significance of CD105 expression for tumor angiogenesis and prognosis in endometrial carcinomas [ J ]. APMIS ,2003 ; 111,1011-1018

同被引文献47

  • 1袁榴娣,丁洁,李震.肺癌中肿瘤抑制基因CEACAM1的选择性拼接与PTB的过表达有关[J].肿瘤防治研究,2006,33(5):320-323. 被引量：8
  • 2Oliveira-Ferrer L,Tilki D,Ziegeler G,et al. Duar role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer[J]. Cancer Res,2004, 64(24): 8932-8938.
  • 3Barnberger AM,Briese J,Gotze J,et al. Stimulation of CEACAMI expression by 12-O-tetradecanoylphorbol-13-acetate(TPA) and calcium ionophore A23187 in endometrial carcinoma cells[J]. Carcinogenesis,2006,27(3): 483-490.
  • 4王玥,刘爱东,庞久玲,刘悦,刘昌岭.CD_(105)在结直肠腺癌组织中的表达及意义[J].山东医药,2007,47(20):27-27. 被引量：17
  • 5Okegawa T,Pong RC,Li Y,et al.The role of cell adhesion molecule in cancer progression and it s application in cancer therapy[J].Acta Biochim Pol,2004,51(2):445-457.
  • 6Ergun S,Kilic N,Ziegeler G,et al.CEA-related cell adhesion molecule 1:a potent angiogenic factor and a major effector of vascular endothelial growth factor[J].Mol Cell,2000,5(2):311-320.
  • 7Tiezzi DG,Fernandez SV,Russo J.Epithelial mesenchymal transition during the neoplastic transformation of human breast epithelial cells by estrogen[J].Oncol,2007,31(4):823-827.
  • 8Hokari M.Matsuda Y,Wakai T,et al.Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma Hep G2 cells[J].Life Sci,2007,81(4):336-345.
  • 9Simeone DM,Ji B,Sanerjee M,et al.CEACAM1,a novel serum biomarker for pancreatic cancer[J].Pancreas,2007,34(4):436-443.
  • 10Liu W,Wei W,Winer D,et al.CEACAM1 impedes thyroid cancer growth but promotes invasiveness:a putative mechanism for early metastases[J].Oncogene,2007,26(19):2747-2758.

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实用肿瘤学杂志
2008年 第1期

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